Abstract
Solid lipid nanoparticles are at the forefront of the quickly expanding field of nanotechnology because of their numerous potentials uses in clinical treatment, research, drug delivery, and other diverse fields. The distinct size-dependent characteristics of solid-lipid nanoparticles present an opportunity to create novel therapies. This experiment was carried out to determine the particle size distribution and the zeta potential of two type of emulsion made using 1g of SLN particles (Ibuprofen/Tristearin/Poloxamer 40) at a ratio 10/20/70. The samples were made into an emulsion measuring 1g of SLN using Ibuprofen/ Tristearin/Poloxamer 407 in the ratio of 10/20/70 by homogenising using an Ultra Turraz K25 Homogeniser at 15,000rpm for 3mins and the other sample using an Ultrasonic Processor at 100% amplitude of 7watts for 1min. Emulsion made using the ultrasonic processor had a better zeta potential of -0.0036v, poly dispersity index of 28.5% and a hydrodynamic DM of 1.2600?m, which means a better stable emulsion as compared to sample made with ultra-homogeniser having a zeta potential of - 0.0008v, poly dispersity index (PDI) of 56% and a hydrodynamic DM of 22.996?m.
Keywords
Solid-lipid nanoparticles, Zeta-potentials, emulsions, Particle size distribution
Citations
IRE Journals:
Adeola Adenitan
"Particle Size Distribution & Zeta Potential of Solid- Lipid Nanoparticles Emulsion" Iconic Research And Engineering Journals Volume 8 Issue 8 2025 Page 266-271
IEEE:
Adeola Adenitan
"Particle Size Distribution & Zeta Potential of Solid- Lipid Nanoparticles Emulsion" Iconic Research And Engineering Journals, 8(8)
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