Anticancer Potential of Blackberry (Rubus fruticosus) Leaf Extracts: A Comprehensive Study of Bioactive Compounds and Their Mechanisms of Action
Abstract
Blackberry (Rubus fruticosus) leaves, traditionally used in herbal medicine, are gaining recognition for their potential anticancer properties. These leaves contain a range of bioactive compounds, including flavonoids, phenolic acids, tannins, alkaloids, and essential oils, which have been shown to exhibit anticancer activity through various mechanisms such as apoptosis induction, inhibition of cancer cell proliferation, suppression of metastasis, and antioxidant effects. This review aims to explore the anticancer potential of blackberry leaf extracts by providing a detailed analysis of its chemical constituents and their biological activities. In vitro and in vivo studies have demonstrated the ability of blackberry leaf extracts to target several cancer types, including breast, colon, and lung cancers, by modulating key molecular pathways involved in cancer progression. Additionally, this paper discusses the molecular mechanisms by which these compounds exert their anticancer effects, including the modulation of cell cycle proteins, apoptosis-related genes, and signaling pathways involved in inflammation and metastasis. Despite promising results from preclinical studies, further clinical trials are needed to fully understand the efficacy and safety of blackberry leaf extracts as potential therapeutic agents for cancer treatment. This review highlights the future potential of blackberry leaves as a natural source of anticancer agents and their potential integration into cancer prevention and adjunct therapies.
Keywords
Blackberry leaves, anticancer properties, bioactive compounds, flavonoids, phenolic acids, tannins, alkaloids, apoptosis, oxidative stress, cell proliferation, metastasis, Rubus fruticosus, molecular mechanisms, cancer therapy.
Citations
IRE Journals:
Kanhaiya S Patel
"Anticancer Potential of Blackberry (Rubus fruticosus) Leaf Extracts: A Comprehensive Study of Bioactive Compounds and Their Mechanisms of Action" Iconic Research And Engineering Journals Volume 8 Issue 6 2024 Page 997-999
IEEE:
Kanhaiya S Patel
"Anticancer Potential of Blackberry (Rubus fruticosus) Leaf Extracts: A Comprehensive Study of Bioactive Compounds and Their Mechanisms of Action" Iconic Research And Engineering Journals, 8(6)
About IRE Journals
IRE Journals is an open access online journals established with an aim to publish high quality of research work in various diciplines. We have more than 6 years in publications. Over 2500+ papers already published.
Important Links
For Authors
Volume 7:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 6:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 5:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 4:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 3:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12