Effect of Magnesium Oxide Nanoparticles on Biofilm Formation Against Multidrug Resistant Klebsiella Pneumoniae Isolates
Abstract
The main purpose of this investigation was to access the impact on biofilm formation, antibacterial activity and anticancer potential of magnesium oxide nanoparticles (MgO NPs) against three multidrug resistant Klebsiella pneumoniae isolates. Agar well diffusion method was applied for the evaluation of antibacterial potential and maximum activity was reported at 2mg in all three isolates (21mm, 29mm, 34mm). MIC and MBC were calculated by broth micro-dilution method, two isolates showed MIC at 1000µg/ml and MBC at 2000µg/ml. While, one isolate showed MIC at 500µg/ml and MBC at 1000µg/ml. Effect of MgO nanoparticles was studied through microtiter plate assay using crystal violet stain. Magnesium oxide nanoparticles exhibited maximum reduction in biofilm formation against K.p3 isolate at the concentration of 1mg/ml that was 63.21% and on established biofilm it was 59.78%. Anticancer potential was accessed by MTT assay, research showed that anticancer activity of MgO NPs was dose-dependent manners so that the higher anticancer activity was correlated with high concentration of nanoparticles. Maximum anticancer activity was observed at the concentration of 500µg/ml that was 56.82-60.54%.
Citations
IRE Journals:
Tahreem Bukhari
"Effect of Magnesium Oxide Nanoparticles on Biofilm Formation Against Multidrug Resistant Klebsiella Pneumoniae Isolates" Iconic Research And Engineering Journals Volume 8 Issue 3 2024 Page 551-556
IEEE:
Tahreem Bukhari
"Effect of Magnesium Oxide Nanoparticles on Biofilm Formation Against Multidrug Resistant Klebsiella Pneumoniae Isolates" Iconic Research And Engineering Journals, 8(3)
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