Ameliorative Effect of Fluoride and Therapeutic Potential of Neem (Azadirachta Indica) in Managing Diet-Induced Diabetes Mellitus
Abstract
Diabetes mellitus (DM) is a chronic metabolic disorder marked by high blood glucose levels, often due to impaired insulin function or production, which contributes significantly to global morbidity and mortality. Factors like diet, lifestyle, and environmental exposures, such as fluoride, can influence the development and progression of DM. Traditional medicinal plants like Neem (Azadirachta indica) have garnered attention for their therapeutic potential in managing diabetes. Known for its anti-inflammatory, anti-diabetic, and antioxidant properties, Neem is widely used in Ayurvedic medicine. This study explores both the ameliorative effects of fluoride and the therapeutic efficacy of Neem in managing diet-induced diabetes. The research aims to identify the bioactive compounds in Neem responsible for its anti-diabetic effects, understand their role in glucose metabolism improvement, review clinical studies on its therapeutic impact, and propose strategies for integrating Neem with conventional diabetes treatments. A comprehensive literature review and experimental trials on Sprague-Dawley rats are designed. Diabetic and control groups will be established, with the diabetic group receiving Neem extract while the control receives a standard antidiabetic. Blood glucose, serum insulin, lipid profiles, inflammatory markers, and histological analysis of pancreatic tissue will be evaluated. Key Neem compounds—nimbin, nimbidin, and azadirachtin—are expected to support ?-cell insulin release, enhance tissue glucose uptake, and reduce intestinal glucose absorption. This study suggests that Neem, at an optimized dose, could serve as an adjunctive therapy for diet-induced DM. Findings underscore the need for well-designed, long-term studies to establish safe dosage equivalents for human use.
Keywords
Diabetes Mellitus, Azadirachta indica, Antidiabetic, Ameliorative, Fluoride, Inflammatory, Neem, HPLC
Citations
IRE Journals:
Dr. Rajesh Verma , Naveena Yadav
"Ameliorative Effect of Fluoride and Therapeutic Potential of Neem (Azadirachta Indica) in Managing Diet-Induced Diabetes Mellitus" Iconic Research And Engineering Journals Volume 7 Issue 11 2024 Page 707-715
IEEE:
Dr. Rajesh Verma , Naveena Yadav
"Ameliorative Effect of Fluoride and Therapeutic Potential of Neem (Azadirachta Indica) in Managing Diet-Induced Diabetes Mellitus" Iconic Research And Engineering Journals, 7(11)
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