Current Volume 8
Abstract
Background: Posaconazole is a widely used antifungal drug known for its potency against various fungal infections. The determination of its potency is crucial for ensuring the appropriate dosage and efficacy of the drug samples. UV spectroscopy is a widely accepted method for the quantitative analysis of pharmaceutical active ingredients of drug samples. There is no study available on determination of potency of posaconazole, marketed in Bangladesh, by UV spectroscopy. Aims & Objectives: The present research work aims to determine the potency of posaconazole drug products of various pharmaceutical companies of Bangladesh using UV spectroscopic method and to discuss the findings. Significant findings: The UV method involves measuring the absorbance of posaconazole. In this study lambda max (?max) was found at 264 nm for posaconazole in methanol . From the absorbance of the standard solutions at different concentrations, the regression equation was found as y = 0.0487x + 0.0088 and the coefficient of determination (R2) was evaluated as 0.9997, which indicated topnotch linearity of the calibration curve and data fitting. The absorbance of samples of four (4) different tablets solutions were measured and the concentrations were calculated using the regression equation. Concentrations were found 19.1752 µg/mL, 18.8542 µg/mL, 19.2806 µg/mL, 19.3094 µg/mL and potency of the samples were evaluated 95.87%, 94.27%, 96.40%, 96.55%, respectively. It was found that all of the drug samples complied with the acceptance level stated in US Pharmacopeia. The decreasing order of potencies of the samples is Sample-4 (of ACI)> Sample-3 (of Opsonin)> Sample-1 (of Square)> Sample-2 (of Square).
Citations
IRE Journals:
Shrabony Mazumder , Rupa Akter , Md. Rafiquzzaman
"Potency of Posaconazole Tablet Formulations Manufactured and Marketed in Bangladesh" Iconic Research And Engineering Journals Volume 7 Issue 11 2024 Page 7-12
IEEE:
Shrabony Mazumder , Rupa Akter , Md. Rafiquzzaman
"Potency of Posaconazole Tablet Formulations Manufactured and Marketed in Bangladesh" Iconic Research And Engineering Journals, 7(11)
About IRE Journals
IRE Journals is an open access online journals established with an aim to publish high quality of research work in various diciplines. We have more than 6 years in publications. Over 2500+ papers already published.
Important Links
For Authors
Volume 7:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11Volume 6:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 5:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 4:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12Volume 3:
Issue 1, Issue 2, Issue 3, Issue 4, Issue 5, Issue 6, Issue 7, Issue 8, Issue 9, Issue 10, Issue 11, Issue 12