Abstract
ABO and RhD variants are the most studied blood groups . ABO incompatible blood transfusions are one of the leading causes of harmful and even fatal transfusion reactions. To prevent this, a universally transfusable blood group has to be created. Progressions are being made towards the modification of blood group B to blood group O. This can be done by removing the antigens from the RBC surface and converting it to universal blood group and this idea was pioneered by Goldstein and colleagues at the New York Blood Center in the early 1980s. The conversion of group B RBCs to O was carried out using ?-galactosidase extracted from coffee beans especially Coffea arabica and Coffea canephora. However, because this enzyme ha poor kinetic properties and low pH optimum, the process was not economically viable but clinical trials showed positive results. The ECO-RBC product can be characterized by various methods like blood group serology, SDS PAGE Western blot, flow cytometry, ELISA etc. Presently, safety and efficacy of ECO RBCs are evaluated by performing more clinical trials.
Keywords
Transfusion reactions,?-galactosidase, Coffea arabica, Coffea canephora, ECO RBC
Citations
IRE Journals:
Ch. Lochana , K. Alekhya , G. Prerana , M. Moulika , B. Srilatha; S. Sivasarthika
"Effect of Coffee Beans Towards Conversion of Blood Group B to Blood Group O" Iconic Research And Engineering Journals Volume 7 Issue 5 2023 Page 228-231
IEEE:
Ch. Lochana , K. Alekhya , G. Prerana , M. Moulika , B. Srilatha; S. Sivasarthika
"Effect of Coffee Beans Towards Conversion of Blood Group B to Blood Group O" Iconic Research And Engineering Journals, 7(5)
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